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Reaction: DSPVShc

Descriptive name:

Oxidation of pravastatin to desacyl pravastatin in hepatocytes

Model:

Recon3D

Reaction:

6.0 h_r + nadph_r + 5.0 ahcys_r + pvs_r → 2.0 h2o_r + nadp_r + 5.0 amet_r + dspvs_r

Metabolites:

Stoichiometry
BiGG ID
Name
2.0
h2o_r
H2O H2O
-6.0
h_r
H+
1.0
nadp_r
Nicotinamide adenine dinucleotide phosphate
-1.0
nadph_r
Nicotinamide adenine dinucleotide phosphate - reduced
-5.0
ahcys_r
S-Adenosyl-L-homocysteine
5.0
amet_r
S-Adenosyl-L-methionine
-1.0
pvs_r
Pravastatin
1.0
dspvs_r
Desacyl dehydro-pravastatin

Default bounds:

(0.0, 1000.0)

Objective coefficient:

0.0

Subsystem:

Drug metabolism

Gene Reaction Rule:

1576_AT1

Genes:

1576_AT1 (CYP3A4)

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Universal reaction ?

External database links

Old identifiers

    DSPVShc

DSPVShc in other models