<?xml version='1.0' encoding='UTF-8'?>
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    <listOfUnitDefinitions>
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          <unit kind="gram" scale="0" multiplier="1" exponent="-1"/>
          <unit kind="second" scale="0" multiplier="3600" exponent="-1"/>
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    </listOfUnitDefinitions>
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        <fbc:listOfFluxObjectives/>
      </fbc:objective>
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    <listOfParameters>
      <parameter value="-100000" id="cobra_default_lb" sboTerm="SBO:0000626" constant="true" units="mmol_per_gDW_per_hr"/>
      <parameter value="100000" id="cobra_default_ub" sboTerm="SBO:0000626" constant="true" units="mmol_per_gDW_per_hr"/>
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      <parameter id="R_EX_co2_e_lower_bound" value="-100" sboTerm="SBO:0000625" constant="true" units="mmol_per_gDW_per_hr"/>
      <parameter id="R_EX_fe2_e_lower_bound" value="-1" sboTerm="SBO:0000625" constant="true" units="mmol_per_gDW_per_hr"/>
      <parameter id="R_EX_fe3_e_lower_bound" value="-1" sboTerm="SBO:0000625" constant="true" units="mmol_per_gDW_per_hr"/>
      <parameter id="R_EX_phe__L_e_lower_bound" value="-1" sboTerm="SBO:0000625" constant="true" units="mmol_per_gDW_per_hr"/>
      <parameter id="R_EX_pi_e_lower_bound" value="-100" sboTerm="SBO:0000625" constant="true" units="mmol_per_gDW_per_hr"/>
      <parameter id="R_EX_h_e_lower_bound" value="-100" sboTerm="SBO:0000625" constant="true" units="mmol_per_gDW_per_hr"/>
      <parameter id="R_EX_h2o_e_lower_bound" value="-100" sboTerm="SBO:0000625" constant="true" units="mmol_per_gDW_per_hr"/>
      <parameter id="R_EX_glc__D_e_lower_bound" value="-1" sboTerm="SBO:0000625" constant="true" units="mmol_per_gDW_per_hr"/>
      <parameter id="R_EX_hco3_e_lower_bound" value="-100" sboTerm="SBO:0000625" constant="true" units="mmol_per_gDW_per_hr"/>
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      <parameter id="R_EX_hdca_e_lower_bound" value="-1" sboTerm="SBO:0000625" constant="true" units="mmol_per_gDW_per_hr"/>
      <parameter id="R_EX_sel_e_lower_bound" value="-1" sboTerm="SBO:0000625" constant="true" units="mmol_per_gDW_per_hr"/>
      <parameter id="R_EX_so4_e_lower_bound" value="-100" sboTerm="SBO:0000625" constant="true" units="mmol_per_gDW_per_hr"/>
      <parameter id="R_EX_his__L_e_lower_bound" value="-1" sboTerm="SBO:0000625" constant="true" units="mmol_per_gDW_per_hr"/>
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      <parameter id="R_EX_i_e_lower_bound" value="-1" sboTerm="SBO:0000625" constant="true" units="mmol_per_gDW_per_hr"/>
      <parameter id="R_EX_val__L_e_lower_bound" value="-1" sboTerm="SBO:0000625" constant="true" units="mmol_per_gDW_per_hr"/>
      <parameter id="R_EX_thr__L_e_lower_bound" value="-1" sboTerm="SBO:0000625" constant="true" units="mmol_per_gDW_per_hr"/>
      <parameter id="R_EX_ile__L_e_lower_bound" value="-1" sboTerm="SBO:0000625" constant="true" units="mmol_per_gDW_per_hr"/>
      <parameter id="R_EX_k_e_lower_bound" value="-1" sboTerm="SBO:0000625" constant="true" units="mmol_per_gDW_per_hr"/>
      <parameter id="R_SK_pre_prot_r_lower_bound" value="-1" sboTerm="SBO:0000625" constant="true" units="mmol_per_gDW_per_hr"/>
      <parameter id="R_EX_leu__L_e_lower_bound" value="-1" sboTerm="SBO:0000625" constant="true" units="mmol_per_gDW_per_hr"/>
      <parameter id="R_EX_lnlc_e_copy1_lower_bound" value="-1" sboTerm="SBO:0000625" constant="true" units="mmol_per_gDW_per_hr"/>
      <parameter id="R_EX_lnlc_e_copy2_lower_bound" value="-1" sboTerm="SBO:0000625" constant="true" units="mmol_per_gDW_per_hr"/>
      <parameter id="R_EX_lys__L_e_lower_bound" value="-1" sboTerm="SBO:0000625" constant="true" units="mmol_per_gDW_per_hr"/>
      <parameter id="R_EX_met__L_e_lower_bound" value="-1" sboTerm="SBO:0000625" constant="true" units="mmol_per_gDW_per_hr"/>
      <parameter id="R_EX_na1_e_lower_bound" value="-1" sboTerm="SBO:0000625" constant="true" units="mmol_per_gDW_per_hr"/>
      <parameter id="R_EX_nh4_e_lower_bound" value="-100" sboTerm="SBO:0000625" constant="true" units="mmol_per_gDW_per_hr"/>
      <parameter id="R_EX_o2_e_lower_bound" value="-100" sboTerm="SBO:0000625" constant="true" units="mmol_per_gDW_per_hr"/>
      <parameter id="R_BIOMASS_mm_1_no_glygln_upper_bound" value="1000" sboTerm="SBO:0000625" constant="true" units="mmol_per_gDW_per_hr"/>
    </listOfParameters>
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      <compartment id="e" name="extracellular space" constant="true"/>
      <compartment id="g" name="golgi apparatus" constant="true"/>
      <compartment id="l" name="lysosome" constant="true"/>
      <compartment id="m" name="mitochondria" constant="true"/>
      <compartment id="n" name="nucleus" constant="true"/>
      <compartment id="r" name="endoplasmic reticulum" constant="true"/>
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        </listOfReactants>
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      <reaction id="R_EX_5adtststerone_e" fast="false" reversible="false" name="5alpha-Dihydrotestosterone exchange" metaid="R_EX_5adtststerone_e" sboTerm="SBO:0000627" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
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        </listOfReactants>
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      <reaction id="R_EX_antipyrene_e" fast="false" reversible="false" name="Antipyrene exchange" metaid="R_EX_antipyrene_e" sboTerm="SBO:0000627" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <sbml:annotation xmlns:sbml="http://www.sbml.org/sbml/level3/version1/core">
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              <bqbiol:is xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
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                  <rdf:li rdf:resource="http://identifiers.org/metanetx.reaction/MNXR95847"/>
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              </bqbiol:is>
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          </rdf:RDF>
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          <speciesReference species="M_antipyrene_e" stoichiometry="1" constant="true"/>
        </listOfReactants>
      </reaction>
      <reaction id="R_DM_dgtp_n" fast="false" reversible="false" name="Demand for dGTP, Nuclear" metaid="R_DM_dgtp_n" sboTerm="SBO:0000628" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <sbml:annotation xmlns:sbml="http://www.sbml.org/sbml/level3/version1/core">
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                  <rdf:li rdf:resource="http://identifiers.org/metanetx.reaction/MNXR97328"/>
                  <rdf:li rdf:resource="http://identifiers.org/seed.reaction/rxn12648"/>
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      </reaction>
      <reaction id="R_DM_dsT_antigen_g" fast="false" reversible="false" name="Demand for  Disialyl-T Antigen,  Golgi Apparatus" metaid="R_DM_dsT_antigen_g" sboTerm="SBO:0000628" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <sbml:annotation xmlns:sbml="http://www.sbml.org/sbml/level3/version1/core">
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              <bqbiol:is xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
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        <sbml:annotation xmlns:sbml="http://www.sbml.org/sbml/level3/version1/core">
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      </reaction>
      <reaction id="R_DM_dttp_m" fast="false" reversible="false" name="DTTP demand" metaid="R_DM_dttp_m" sboTerm="SBO:0000628" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <sbml:annotation xmlns:sbml="http://www.sbml.org/sbml/level3/version1/core">
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
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              <bqbiol:is xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
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                  <rdf:li rdf:resource="http://identifiers.org/bigg.reaction/DM_dttp_m"/>
                  <rdf:li rdf:resource="http://identifiers.org/metanetx.reaction/MNXR97810"/>
                  <rdf:li rdf:resource="http://identifiers.org/seed.reaction/rxn09686"/>
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              </bqbiol:is>
            </rdf:Description>
          </rdf:RDF>
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          <speciesReference species="M_dttp_m" stoichiometry="1" constant="true"/>
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      <reaction id="R_DM_dttp_n" fast="false" reversible="false" name="Demand for dTTP, Nuclear" metaid="R_DM_dttp_n" sboTerm="SBO:0000628" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <sbml:annotation xmlns:sbml="http://www.sbml.org/sbml/level3/version1/core">
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              <bqbiol:is xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
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                  <rdf:li rdf:resource="http://identifiers.org/seed.reaction/rxn09686"/>
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      <reaction id="R_DM_ethamp_r" fast="false" reversible="false" name="Ethanolamine phosphate demand" metaid="R_DM_ethamp_r" sboTerm="SBO:0000628" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <sbml:annotation xmlns:sbml="http://www.sbml.org/sbml/level3/version1/core">
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
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              <bqbiol:is xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
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                  <rdf:li rdf:resource="http://identifiers.org/bigg.reaction/DM_ethamp_r"/>
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          <speciesReference species="M_ethamp_r" stoichiometry="1" constant="true"/>
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      <reaction id="R_DM_gncore2_g" fast="false" reversible="false" name="Demand for gncore  2, Golgi Apparatus" metaid="R_DM_gncore2_g" sboTerm="SBO:0000628" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <sbml:annotation xmlns:sbml="http://www.sbml.org/sbml/level3/version1/core">
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              <bqbiol:is xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
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          <speciesReference species="M_gncore2_g" stoichiometry="1" constant="true"/>
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      </reaction>
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          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
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          <speciesReference species="M_gpi_sig_r" stoichiometry="1" constant="true"/>
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        <sbml:annotation xmlns:sbml="http://www.sbml.org/sbml/level3/version1/core">
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        <sbml:annotation xmlns:sbml="http://www.sbml.org/sbml/level3/version1/core">
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              <bqbiol:is xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
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      <reaction id="R_DM_kdn_c" fast="false" reversible="false" name="Demand for  2-Keto-3-Deoxy-D-Glycero-D-Galactononic Acid,  Cytosolic" metaid="R_DM_kdn_c" sboTerm="SBO:0000628" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <sbml:annotation xmlns:sbml="http://www.sbml.org/sbml/level3/version1/core">
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      <reaction id="R_EX_apnnox_e" fast="false" reversible="false" name="Alpha-Pinene-oxide exchange" metaid="R_EX_apnnox_e" sboTerm="SBO:0000627" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
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      <reaction id="R_DM_melanin_c" fast="false" reversible="false" name="Demand for Melanin, Cytosolic" metaid="R_DM_melanin_c" sboTerm="SBO:0000628" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <sbml:annotation xmlns:sbml="http://www.sbml.org/sbml/level3/version1/core">
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      <reaction id="R_EX_aprgstrn_e" fast="false" reversible="false" name="20alpha-Hydroxyprogesterone exchange" metaid="R_EX_aprgstrn_e" sboTerm="SBO:0000627" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
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      <reaction id="R_EX_aqcobal_e" fast="false" reversible="false" name="Aquacob(III)alamin exchange" metaid="R_EX_aqcobal_e" sboTerm="SBO:0000627" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
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      <reaction id="R_EX_25hvitd2_e" fast="false" reversible="false" name="25-Hydroxyvitamin D2 exchange" metaid="R_EX_25hvitd2_e" sboTerm="SBO:0000627" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
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      <reaction id="R_EX_bildglcur_e" fast="false" reversible="false" name="Bilirubin beta-diglucuronide exchange" metaid="R_EX_bildglcur_e" sboTerm="SBO:0000627" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
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        <sbml:annotation xmlns:sbml="http://www.sbml.org/sbml/level3/version1/core">
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        <sbml:annotation xmlns:sbml="http://www.sbml.org/sbml/level3/version1/core">
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                  <rdf:li rdf:resource="http://identifiers.org/rhea/34915"/>
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                  <rdf:li rdf:resource="http://identifiers.org/rhea/28465"/>
                  <rdf:li rdf:resource="http://identifiers.org/rhea/28463"/>
                  <rdf:li rdf:resource="http://identifiers.org/rhea/28464"/>
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                  <rdf:li rdf:resource="http://identifiers.org/rhea/28470"/>
                  <rdf:li rdf:resource="http://identifiers.org/rhea/28473"/>
                  <rdf:li rdf:resource="http://identifiers.org/rhea/28471"/>
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                  <rdf:li rdf:resource="http://identifiers.org/metanetx.reaction/MNXR103384"/>
                  <rdf:li rdf:resource="http://identifiers.org/sabiork/12168"/>
                  <rdf:li rdf:resource="http://identifiers.org/seed.reaction/rxn10929"/>
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              <fbc:and>
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              <fbc:and>
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              <fbc:and>
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