<?xml version='1.0' encoding='UTF-8'?>
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  <model fbc:strict="true" id="iCHOv1_DG44">
    <listOfUnitDefinitions>
      <unitDefinition id="mmol_per_gDW_per_hr">
        <listOfUnits>
          <unit kind="mole" scale="-3" multiplier="1" exponent="1"/>
          <unit kind="gram" scale="0" multiplier="1" exponent="-1"/>
          <unit kind="second" scale="0" multiplier="3600" exponent="-1"/>
        </listOfUnits>
      </unitDefinition>
    </listOfUnitDefinitions>
    <fbc:listOfObjectives fbc:activeObjective="obj">
      <fbc:objective fbc:id="obj" fbc:type="maximize">
        <fbc:listOfFluxObjectives>
          <fbc:fluxObjective fbc:reaction="R_BIOMASS_cho_producing_1" fbc:coefficient="1"/>
        </fbc:listOfFluxObjectives>
      </fbc:objective>
    </fbc:listOfObjectives>
    <listOfParameters>
      <parameter value="-1000" id="cobra_default_lb" sboTerm="SBO:0000626" constant="true" units="mmol_per_gDW_per_hr"/>
      <parameter value="1000" id="cobra_default_ub" sboTerm="SBO:0000626" constant="true" units="mmol_per_gDW_per_hr"/>
      <parameter value="0" id="cobra_0_bound" sboTerm="SBO:0000626" constant="true" units="mmol_per_gDW_per_hr"/>
      <parameter id="R_EX_arg__L_e_upper_bound" value="-0.02013" sboTerm="SBO:0000625" constant="true" units="mmol_per_gDW_per_hr"/>
      <parameter id="R_EX_arg__L_e_lower_bound" value="-0.02013" sboTerm="SBO:0000625" constant="true" units="mmol_per_gDW_per_hr"/>
      <parameter id="R_EX_asn__L_e_upper_bound" value="-0.04058" sboTerm="SBO:0000625" constant="true" units="mmol_per_gDW_per_hr"/>
      <parameter id="R_EX_asn__L_e_lower_bound" value="-0.04058" sboTerm="SBO:0000625" constant="true" units="mmol_per_gDW_per_hr"/>
      <parameter id="R_EX_asp__L_e_upper_bound" value="-0.00976" sboTerm="SBO:0000625" constant="true" units="mmol_per_gDW_per_hr"/>
      <parameter id="R_EX_asp__L_e_lower_bound" value="-0.00976" sboTerm="SBO:0000625" constant="true" units="mmol_per_gDW_per_hr"/>
      <parameter id="R_EX_ala__L_e_upper_bound" value="0.0113" sboTerm="SBO:0000625" constant="true" units="mmol_per_gDW_per_hr"/>
      <parameter id="R_EX_ala__L_e_lower_bound" value="0.0113" sboTerm="SBO:0000625" constant="true" units="mmol_per_gDW_per_hr"/>
      <parameter id="R_EX_cys__L_e_upper_bound" value="-0.00539" sboTerm="SBO:0000625" constant="true" units="mmol_per_gDW_per_hr"/>
      <parameter id="R_EX_cys__L_e_lower_bound" value="-0.00539" sboTerm="SBO:0000625" constant="true" units="mmol_per_gDW_per_hr"/>
      <parameter id="R_EX_glc__D_e_upper_bound" value="-0.1979" sboTerm="SBO:0000625" constant="true" units="mmol_per_gDW_per_hr"/>
      <parameter id="R_EX_glc__D_e_lower_bound" value="-0.1979" sboTerm="SBO:0000625" constant="true" units="mmol_per_gDW_per_hr"/>
      <parameter id="R_EX_gln__L_e_upper_bound" value="-0.0674" sboTerm="SBO:0000625" constant="true" units="mmol_per_gDW_per_hr"/>
      <parameter id="R_EX_gln__L_e_lower_bound" value="-0.0674" sboTerm="SBO:0000625" constant="true" units="mmol_per_gDW_per_hr"/>
      <parameter id="R_EX_glu__L_e_upper_bound" value="0.0095" sboTerm="SBO:0000625" constant="true" units="mmol_per_gDW_per_hr"/>
      <parameter id="R_EX_glu__L_e_lower_bound" value="0.0095" sboTerm="SBO:0000625" constant="true" units="mmol_per_gDW_per_hr"/>
      <parameter id="R_EX_gly_e_upper_bound" value="0.0209" sboTerm="SBO:0000625" constant="true" units="mmol_per_gDW_per_hr"/>
      <parameter id="R_EX_gly_e_lower_bound" value="0.0209" sboTerm="SBO:0000625" constant="true" units="mmol_per_gDW_per_hr"/>
      <parameter id="R_EX_his__L_e_upper_bound" value="-0.00407" sboTerm="SBO:0000625" constant="true" units="mmol_per_gDW_per_hr"/>
      <parameter id="R_EX_his__L_e_lower_bound" value="-0.00407" sboTerm="SBO:0000625" constant="true" units="mmol_per_gDW_per_hr"/>
      <parameter id="R_EX_ile__L_e_upper_bound" value="-0.01055" sboTerm="SBO:0000625" constant="true" units="mmol_per_gDW_per_hr"/>
      <parameter id="R_EX_ile__L_e_lower_bound" value="-0.01055" sboTerm="SBO:0000625" constant="true" units="mmol_per_gDW_per_hr"/>
      <parameter id="R_EX_phe__L_e_upper_bound" value="-0.00592" sboTerm="SBO:0000625" constant="true" units="mmol_per_gDW_per_hr"/>
      <parameter id="R_EX_phe__L_e_lower_bound" value="-0.00592" sboTerm="SBO:0000625" constant="true" units="mmol_per_gDW_per_hr"/>
      <parameter id="R_EX_lac__L_e_upper_bound" value="0.1208" sboTerm="SBO:0000625" constant="true" units="mmol_per_gDW_per_hr"/>
      <parameter id="R_EX_lac__L_e_lower_bound" value="0.1208" sboTerm="SBO:0000625" constant="true" units="mmol_per_gDW_per_hr"/>
      <parameter id="R_EX_pro__L_e_upper_bound" value="-0.00847" sboTerm="SBO:0000625" constant="true" units="mmol_per_gDW_per_hr"/>
      <parameter id="R_EX_pro__L_e_lower_bound" value="-0.00847" sboTerm="SBO:0000625" constant="true" units="mmol_per_gDW_per_hr"/>
      <parameter id="R_EX_leu__L_e_upper_bound" value="-0.01567" sboTerm="SBO:0000625" constant="true" units="mmol_per_gDW_per_hr"/>
      <parameter id="R_EX_leu__L_e_lower_bound" value="-0.01567" sboTerm="SBO:0000625" constant="true" units="mmol_per_gDW_per_hr"/>
      <parameter id="R_EX_lys__L_e_upper_bound" value="-0.01403" sboTerm="SBO:0000625" constant="true" units="mmol_per_gDW_per_hr"/>
      <parameter id="R_EX_lys__L_e_lower_bound" value="-0.01403" sboTerm="SBO:0000625" constant="true" units="mmol_per_gDW_per_hr"/>
      <parameter id="R_EX_met__L_e_upper_bound" value="-0.00632" sboTerm="SBO:0000625" constant="true" units="mmol_per_gDW_per_hr"/>
      <parameter id="R_EX_met__L_e_lower_bound" value="-0.00632" sboTerm="SBO:0000625" constant="true" units="mmol_per_gDW_per_hr"/>
      <parameter id="R_EX_ser__L_e_upper_bound" value="-0.04813" sboTerm="SBO:0000625" constant="true" units="mmol_per_gDW_per_hr"/>
      <parameter id="R_EX_ser__L_e_lower_bound" value="-0.04813" sboTerm="SBO:0000625" constant="true" units="mmol_per_gDW_per_hr"/>
      <parameter id="R_EX_nh4_e_upper_bound" value="0.08332" sboTerm="SBO:0000625" constant="true" units="mmol_per_gDW_per_hr"/>
      <parameter id="R_EX_nh4_e_lower_bound" value="0.08332" sboTerm="SBO:0000625" constant="true" units="mmol_per_gDW_per_hr"/>
      <parameter id="R_EX_trp__L_e_upper_bound" value="-0.0032" sboTerm="SBO:0000625" constant="true" units="mmol_per_gDW_per_hr"/>
      <parameter id="R_EX_trp__L_e_lower_bound" value="-0.0032" sboTerm="SBO:0000625" constant="true" units="mmol_per_gDW_per_hr"/>
      <parameter id="R_EX_o2_e_upper_bound" value="-1.125" sboTerm="SBO:0000625" constant="true" units="mmol_per_gDW_per_hr"/>
      <parameter id="R_EX_o2_e_lower_bound" value="-1.125" sboTerm="SBO:0000625" constant="true" units="mmol_per_gDW_per_hr"/>
      <parameter id="R_EX_thr__L_e_upper_bound" value="-0.01058" sboTerm="SBO:0000625" constant="true" units="mmol_per_gDW_per_hr"/>
      <parameter id="R_EX_thr__L_e_lower_bound" value="-0.01058" sboTerm="SBO:0000625" constant="true" units="mmol_per_gDW_per_hr"/>
      <parameter id="R_EX_tyr__L_e_upper_bound" value="-0.00982" sboTerm="SBO:0000625" constant="true" units="mmol_per_gDW_per_hr"/>
      <parameter id="R_EX_tyr__L_e_lower_bound" value="-0.00982" sboTerm="SBO:0000625" constant="true" units="mmol_per_gDW_per_hr"/>
      <parameter id="R_EX_val__L_e_upper_bound" value="-0.01246" sboTerm="SBO:0000625" constant="true" units="mmol_per_gDW_per_hr"/>
      <parameter id="R_EX_val__L_e_lower_bound" value="-0.01246" sboTerm="SBO:0000625" constant="true" units="mmol_per_gDW_per_hr"/>
      <parameter id="R_SK_Asn_X_Ser_Thr_r_lower_bound" value="-0.1" sboTerm="SBO:0000625" constant="true" units="mmol_per_gDW_per_hr"/>
      <parameter id="R_SK_Ser_Thr_g_lower_bound" value="-0.1" sboTerm="SBO:0000625" constant="true" units="mmol_per_gDW_per_hr"/>
      <parameter id="R_SK_Tyr_ggn_c_lower_bound" value="-0.1" sboTerm="SBO:0000625" constant="true" units="mmol_per_gDW_per_hr"/>
      <parameter id="R_DM_igg_g_upper_bound" value="1.303e-05" sboTerm="SBO:0000625" constant="true" units="mmol_per_gDW_per_hr"/>
      <parameter id="R_DM_igg_g_lower_bound" value="1.303e-05" sboTerm="SBO:0000625" constant="true" units="mmol_per_gDW_per_hr"/>
      <parameter id="R_SK_pre_prot_r_lower_bound" value="-0.1" sboTerm="SBO:0000625" constant="true" units="mmol_per_gDW_per_hr"/>
    </listOfParameters>
    <listOfCompartments>
      <compartment id="c" name="cytosol" constant="true"/>
      <compartment id="x" name="peroxisome/glyoxysome" constant="true"/>
      <compartment id="r" name="endoplasmic reticulum" constant="true"/>
      <compartment id="m" name="mitochondria" constant="true"/>
      <compartment id="mm" name="mitochondrial intermembrane" constant="true"/>
      <compartment id="e" name="extracellular space" constant="true"/>
      <compartment id="g" name="golgi apparatus" constant="true"/>
      <compartment id="n" name="nucleus" constant="true"/>
      <compartment id="l" name="lysosome" constant="true"/>
      <compartment id="im" name="intermembrane space of mitochondria" constant="true"/>
    </listOfCompartments>
    <listOfSpecies>
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                <rdf:Bag>
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                  <rdf:li rdf:resource="http://identifiers.org/biocyc/META:HCO3"/>
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                  <rdf:li rdf:resource="http://identifiers.org/chebi/CHEBI:28976"/>
                  <rdf:li rdf:resource="http://identifiers.org/chebi/CHEBI:5589"/>
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                  <rdf:li rdf:resource="http://identifiers.org/hmdb/HMDB00595"/>
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      <reaction id="R_EX_cyan_e" fast="false" reversible="false" name="Hydrogen cyanide exchange" metaid="R_EX_cyan_e" sboTerm="SBO:0000627" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
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      <reaction id="R_EX_galfucgalacglcgal14acglcgalgluside_cho_e" fast="false" reversible="false" name="(Gal)4 (Glc)1 (GlcNAc)2 (LFuc)1 (Cer)1 exchange" metaid="R_EX_galfucgalacglcgal14acglcgalgluside_cho_e" sboTerm="SBO:0000627" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
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      <reaction id="R_EX_galgalfucfucgalacglcgalacglcgal14acglcgalgluside_cho_e" fast="false" reversible="false" name="(Gal)6 (Glc)1 (GlcNAc)3 (LFuc)2 (Cer)1 exchange" metaid="R_EX_galgalfucfucgalacglcgalacglcgal14acglcgalgluside_cho_e" sboTerm="SBO:0000627" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
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      <reaction id="R_EX_galside_cho_e" fast="false" reversible="false" name="D-galactosyl-N-acylsphingosine exchange" metaid="R_EX_galside_cho_e" sboTerm="SBO:0000627" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
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      <reaction id="R_EX_cys__L_e" fast="false" reversible="true" name="L-Cysteine exchange" metaid="R_EX_cys__L_e" sboTerm="SBO:0000627" fbc:upperFluxBound="R_EX_cys__L_e_upper_bound" fbc:lowerFluxBound="R_EX_cys__L_e_lower_bound">
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                  <rdf:li rdf:resource="http://identifiers.org/rhea/29655"/>
                  <rdf:li rdf:resource="http://identifiers.org/rhea/29656"/>
                  <rdf:li rdf:resource="http://identifiers.org/rhea/29658"/>
                  <rdf:li rdf:resource="http://identifiers.org/rhea/29657"/>
                  <rdf:li rdf:resource="http://identifiers.org/sabiork/13465"/>
                  <rdf:li rdf:resource="http://identifiers.org/seed.reaction/rxn08284"/>
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                  <rdf:li rdf:resource="http://identifiers.org/seed.reaction/rxn08286"/>
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      <reaction id="R_ALAALACNc" fast="false" reversible="false" name="Hydrolysis of Alanylalanine" metaid="R_ALAALACNc" sboTerm="SBO:0000176" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
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          <speciesReference species="M_alaala_c" stoichiometry="1" constant="true"/>
          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
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        <listOfProducts>
          <speciesReference species="M_ala__L_c" stoichiometry="2" constant="true"/>
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      <reaction id="R_EX_cysam_e" fast="false" reversible="false" name="Exchange reaction for cysam" metaid="R_EX_cysam_e" sboTerm="SBO:0000627" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
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      <reaction id="R_EX_cytd_e" fast="false" reversible="false" name="Cytidine exchange" metaid="R_EX_cytd_e" sboTerm="SBO:0000627" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
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      <reaction id="R_ALAALAPEPT1tc" fast="false" reversible="false" name="Transport of Alanylalanine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells" metaid="R_ALAALAPEPT1tc" sboTerm="SBO:0000185" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
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      <reaction id="R_EX_digalsgalside_cho_e" fast="false" reversible="false" name="Digalactosylceramidesulfate exchange" metaid="R_EX_digalsgalside_cho_e" sboTerm="SBO:0000627" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
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      <reaction id="R_EX_dmantipyrine_e" fast="false" reversible="false" name="Demethylated antipyrine exchange" metaid="R_EX_dmantipyrine_e" sboTerm="SBO:0000627" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <sbml:annotation xmlns:sbml="http://www.sbml.org/sbml/level3/version1/core">
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        <sbml:annotation xmlns:sbml="http://www.sbml.org/sbml/level3/version1/core">
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                  <rdf:li rdf:resource="http://identifiers.org/reactome.reaction/R-GGA-372542"/>
                  <rdf:li rdf:resource="http://identifiers.org/reactome.reaction/R-CFA-372542"/>
                  <rdf:li rdf:resource="http://identifiers.org/reactome.reaction/R-BTA-372542"/>
                  <rdf:li rdf:resource="http://identifiers.org/reactome.reaction/R-CEL-372542"/>
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                  <rdf:li rdf:resource="http://identifiers.org/reactome.reaction/R-MMU-372542"/>
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                  <rdf:li rdf:resource="http://identifiers.org/reactome.reaction/R-HSA-351596"/>
                  <rdf:li rdf:resource="http://identifiers.org/sabiork/7032"/>
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                  <rdf:li rdf:resource="http://identifiers.org/rhea/28467"/>
                  <rdf:li rdf:resource="http://identifiers.org/rhea/28469"/>
                  <rdf:li rdf:resource="http://identifiers.org/rhea/28466"/>
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                  <rdf:li rdf:resource="http://identifiers.org/rhea/45266"/>
                  <rdf:li rdf:resource="http://identifiers.org/rhea/45265"/>
                  <rdf:li rdf:resource="http://identifiers.org/rhea/45264"/>
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                  <rdf:li rdf:resource="http://identifiers.org/rhea/28463"/>
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                  <rdf:li rdf:resource="http://identifiers.org/rhea/33172"/>
                  <rdf:li rdf:resource="http://identifiers.org/rhea/33171"/>
                  <rdf:li rdf:resource="http://identifiers.org/rhea/33174"/>
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                  <rdf:li rdf:resource="http://identifiers.org/seed.reaction/rxn08874"/>
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                  <rdf:li rdf:resource="http://identifiers.org/rhea/34874"/>
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